A fifth wheel : When something or someone is or feels not wanted or useless
Backseat driver : A passenger who gives the driver unwanted advice
To miss the boat : To miss an opportunity because you don't act quickly enough
Running on empty : To have almost no resources, like a car who is out of petrol
To have a itchy feet : To feel the nees to travel
To hit the road : To leave a workplace or a job that is not going very well for another
To jump ship : To leave, to begin a journey
To ship someone off : To send someone away somewhere